Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro

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Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro.

In brain stem slices from neonatal (postnatal days 0-4) CD-1 mice, muscarinic ACh receptors (MAChRs) increased rhythmic inspiratory-related and tonic hypoglossal nerve discharge and depolarized single hypoglossal motoneurons (HMs) via an inward current without changing input resistance. These responses were blocked by the MAChR antagonist 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAM...

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ژورنال

عنوان ژورنال: Journal of Applied Physiology

سال: 2012

ISSN: 8750-7587,1522-1601

DOI: 10.1152/japplphysiol.00699.2011